We have just posted a Technical Report on extrachromosomal DNA, ecDNA. These are small circular DNA segments that contain proto-oncogenes that are often transcription factors enhancing malignant cells. They are just another element in what we see as cancer cells. They have been known for decades but with new techniques and instruments their impact has become more understood.
It should be noted that NCI awarded a substantial grant in this area last year to a group of the authors referred to.
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