Vaccines

 In a recent note in Science they discussed the facts that COVID vaccines have limited effectiveness as compared to other vaccines. They note:

Neither vaccinations nor immunity from infections seem to thwart SARS-CoV-2 for long. The frequency of new infections within a few months of a previous bout or a shot is one of COVID-19’s most vexing puzzles. Now, scientists have learned that a little-known type of immune cell in the bone marrow may play a major role in this failure. The study, which appeared last month in Nature Medicine, found that people who received repeated doses of vaccine, and in some cases also became infected with SARS-CoV-2, largely failed to make special antibody-producing cells called long-lived plasma cells (LLPCs). “That’s really, really interesting,” says Mark Slifka, an immunologist at the Oregon Health & Science University who was not involved with the work. The study authors say their finding may indicate a way to make better COVID-19 vaccines: by altering how they present the spike surface protein of SARS-CoV-2 to a person’s immune cells. Durability is an age-old bugaboo of vaccine designers. Some vaccines, particularly ones made from weakened versions of viruses, can protect people for decades, even life. Yet others lose effectiveness within months. “We really haven’t overcome this challenge,” says Akiko Iwasaki, a Yale University immunologist who is developing a nasal COVID-19 vaccine she hopes can be given often enough to get around the durability problem.

 My 1944 smallpox immunity still works as does my 1953 polio. However my mRNA COVID kind of lasts six months at best. The observation noted above about immune cell surface proteins, receptors, has merit. However the flu shots last about six months. Perhaps the mutation rate of single stranded mRNA viruses is at fault.

One suspects dramatic changes in vaccines now that we have a window to their operations.