Friday, July 30, 2021

The Variants

 

Ok so here are the variants. The mutations are shown. Delta has multiple mutations resulting in changes in amino acids. Simply stated if we go from G (glycine) on site 142 on the spike protein to aspartic acid, D in the same site we have gone from a neutral to acidic amino acid, and thus change the bonding to the ACE2 receptor. The other mutations can be determined equally. Thus we go from the "wild" type to the Delta variant and allegedly get better bonding.

Now we can review what we said over a year ago.

1. The spike protein is temperature sensitive. In the nasopharynx it is 94F and the protein does not bond with ACE2, it is wrapped too tight. 

2. As the virion gets into the lung the temperature increases, the protein opens and bonds. Then we get an infection.

3. However if are vaccinated the Ab attach and the T cells delete the virus. Done!

4. However, and we said this almost a year and a half ago, the nasopharynx if exposed to Delta keeps Delta alone for 24-48 hours until destroyed by the innate immune system. I leave the details to the reader.

5. Immunized or not the nasopharynx expels the virions in aerosols.

6. However, and this is still a fact, we have no clue as to the physics of this process. If the particles ate nm in size, which they are, mask or no mask we have a problem. We need at least a Level 3 facility to manage this.

7. The solution is measuring the infected, immunized etc. The CDC seems clueless here. 

8. The real only solution is universal vaccination, the Delta will die out.

9. However, if we do not kill it off, it will mutate again and we are back to ground zero.

10. We need effective communicators not the wanton self promoters we now have. Time is of the essence. None of the above is new! What is "new" is the "story tellers" either gross incompetence or their refulsal for reasons unknown to have told the truth from the outset.